Engineering of Live Chimeric Vaccines against Human Metapneumovirus

Evaluation of Live Attenuated Measles Vaccines Prepared in Human Diploid Cells for Reimmunization

Preventive and Therapeutic Vaccines against Human Papillomaviruses Associated Cervical Cancers

Cervical cancer is, globally known to be, one of the most common cancers among women especially indeveloping countries. More than 90% of cervical cancers are associated with high-risk humanpapillomaviruses (HPVs) particularly HPV types 16 and 18. Two major strategies have been developed forprevention and treatment of cervical cancer and other HPV-associated malignancies; the first one is based ...

Vaccines against human papillomavirus.

Human papillomavirus has been identified as an etiological factor for cervical cancer, anogenital cancers and a subset of head and neck cancers. These important observations suggest that HPV vaccines have potential in the prevention and treatment of cervical cancer and other HPV-associated malignancies. The HPV genome encodes two HPV late genes, L1 and L2, which form the viral capsid. Early vir...

Chimeric DNA Vaccines against ErbB2+ Carcinomas: From Mice to Humans

DNA vaccination exploits a relatively simple and flexible technique to generate an immune response against microbial and tumor-associated antigens (TAAs). Its effectiveness is enhanced by the application of an electrical shock in the area of plasmid injection (electroporation). In our studies we exploited a sophisticated electroporation device approved for clinical use (Cliniporator, IGEA, Carp...

Alphavirus virus-based chimeric vaccines against encephalitic alphaviruses

Encephalitic viruses in the Family Togaviridae, genus Alphavirus are zoonotic pathogens that are transmitted via hematophagous arthropods and have a widespread distribution in North, Central and South America and include Venezuelan equine encephalitis virus (VEEV), Western equine encephalitis virus (WEEV), Eastern equine encephalitis virus (EEEV). The deficit in specific antiviral drugs or vacc...